Dynamical Downscaling for Climate Model Projections

Does anyone have experience with running high-resolution climate models on a regional sub-domain, i.e. dynamical downscaling for climate studies and climate projections? Specifically, I am interested in the SRES A2 Scenario (Special Report on Emissions Scenario) in PRECIS Model. Could you please give me some advice on how to use it and share some research papers on the subject?