Pure water distribution system in pharmaceutical company

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Dear all

I need information about purified water loop in pharmaceutical company.  PW water with USP (United State Pharmacopeia) specs (i.e., EC

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11 Answers

  1. An automated control system could help

    Hi Hossein.

    My company geos has a specialty in developing automated water loops to control variables and readings. I Think the group has posted good data concerning to your request. In my opinion you should implement that posted above and a system of control with data log and alarms of behavior. That is our specialty.

    Best Regards.

  2. velocity, ozone and CO2

    You must design the loop to maintain  1 m/s at the end.

    The best option is control de pump with a VFD and a flowmeter at the end of the loop.

    After the RO plant you must install a degassing system or a contactor membranes (Liquicell) to remove the CO2.

    You must install a ozone generator feed with oxygen, not by air.

    Closed reservoir tank of course with a presure discharge check valve and a vacuum security valve.

    All the valves in AISI 316L food quality and the tank in the same material.

    UV lamp for eliminate the ozone residual.

     

  4. Dear all Thank you so much for your responses. However, how can we prevent CO2 absorption in PW water when the water temperature is about 25 oC? Besides, I think CO2 absorption is more feasible when ozone is injected in water. Because product gas of ozone generator contains CO2 gas. However, would you please introduce me any reference that described all of the mentioned criteria in detail? Regards

  5. Surely CO2 will change water characteristic. No free CO2 allowed in EDI as it will change FCE(feed conductivity equivalence). As stated above by others velocity (return water) is important. You will have to ensure zero dead lag and bacteria free condition.

  7. You have Water conductivity as per USP guidelines, Other required parameters are as follows: pH 5.0 – 7.0 Conductivity ≤ 1.3 @ 25ºC µS/cm TOC

  8. BEFORE R.O. YOU CAN USE OUR PRODUCT "CHLORITARD" FOR DIS-INFECTION WITH 0.002 - 0.005 PPM WHERE-IN ALL "PATHOGENS + G.I. DISEASES" ARE ELIMINATED. JUST PUT THE POUCH IN STORAGE TANK PRIOR TO R.O.. THIS CAN ALSO BE USED FOR "AGRICULTURE" PURPOSES INSTAED OF USING FERTILIZERS TO THE PLANTS, VEGETABLES, FRUITS TO ELIMINATE VIRUSES, DISEASES, LATER. (2) CHLORITARD : WHO - HOUSEHOLD WATER TREATMENT (HWT) - WATER TREATMENT FOR "PATHOGEN + G.I. DISEASE FREE" HOUSEHOLD CONSUMING SAFE WATER. The most effective technology best suited for point of consumption water disinfection. Chloritard can be simply described as “scientist’s dream product” as it fulfills all the criteria THUS, HOUSEHOLD CONSUMING SAFE WATER AFTER USING CHLORITARD CAN BE USED FOR - HAND WASH, BATHING, CLEANING UTENSILS, COOKING, CLOTHES WASHING (including DRINKING). US$ 7.95 / 15,000 Liters (500 LTRS TANK X 30 DAYS) AT NEGLIGIBLE COST = US$ 0.0001 - US$ 0.0008 / LITER (FOR 30 DAYS), DEPENDING ON THE WATER RESERVOIR / TANK TREATED AS PER CAPACITY OF TANK (100 LITERS - 50,000 LTRS X 30 DAYS) FOR 30 DAYS. CHLORITARD - 30 DAYS - CONTROL OF (CHLORINE = 0.5 PPM)REGULATING POUCH FOR WATER STORAGE TANKS IN TOWNS / VILLAGES / APPARTMENTS / BUNGALOWS : =================================================================CHLORITARD IS SAFE WATER CONTROLLING POUCH FOR WAYER STORAGE TANS / OVER-HEAD TANKS IN APPARTMENTS / BUNGALOWS / STORAGE TANKS MAINTAINING "CHLORINE = 0.5 ppm", THUS SAFE WATER, CLEAN FROM CONTAMINATION, SAVES MONEY ON DOCTOR / MEDICAL ILLNESS. Thus it can be said that Chloritard a month - KEEPS A DOCTOR AWAY. CHLORITARD - WATER TREATMENT FOR "PATHOGEN + G.I. DISEASE FREE" HOUSEHOLD CONSUMING SAFE WATER. THUS, SAFE HOUSEHOLD CONSUMING SAFE WATER AFTER USING CHLORITARD CAN BE USED FOR - HAND WASH, BATHING, CLEANING UTENSILS, COOKING, CLOTHES WASHING (Including DRINKING) SIZES : AVAILABLE IN "POUCHES" SUITABLE FOR "CHLORINE = 0.5 ppm" REGULATION / CONTROL DEPENDING ON STORAGE TANK SIZE LITERS = 100 LITER - 50,000 LITERS X 30 DAYS (CHLORINE CONTROL = 0.5 PPM). SO, 1 POUCH FOR 500 LITERS IF PURCHASED, CONTROLS CHLORINE = 0.5 PPM FOR 30 DAYS. i.e. US$ 7.95 (1 POUCH) CHLORITARD FOR 500 LTRS X 30 DAYS = 15,000 LITERS / MONTH = RESERVOIR TANK - TREATED - CONTROL OF CHLORINE = 0.5 PPM (KILLING : PATHOGENS + G.I. DISEASE) AT NEGLIGIBLE PRICE / COST = US$ 0.0005 / LITRE. THANKS & BEST REGARDS, JACKY / SHAILESH sourcing_imports@yahoo.com

  9. Hi Hossein, See under: Carbon Dioxide and pH. http://www.fondriest.com/environmental-measurements/parameters/water-quality/ph/ And also: http://www.telstar-lifesciences.com/technologies/pw%20wfi%20and%20pharmaceutical%20steam/storage%20and%20distribution%20systems%20for%20pharmaceutical%20quality%20water/purified%20water%20and%20water%20for%20injection%20distribution%20loops.htm Regards, Patrick

  10. Dear Hossein, of course Carbon Dioxide affects the quality of water, due to the fact that the reaction between CO2 and water produce carbonic acid (H2CO3 which dissociate into H+ and HCO3-). This reaction increases significantly the electrical conductivity, and if you have a value 1 m/s, continuos control of electrical conductivity shall be installed on the loop and a UV lamp to control bacterial growth. If you can provide further information, it could be possible to give you more hints about the system and its maintenance. Regards

  11. Carbonic acid will reduce the pH slightly. I do not think it would affect the quality of water used for formulation. Also before RO, we have to treat the water (disinfection etc), but higher concentration of any chemical disinfection will degrade the quality of RO membrane. But usually UV or O3 treatment will eliminate this. But suspended solids is a strict no.